Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 2008 Apr 16;582(9):1293-7. doi: 10.1016/j.febslet.2008.03.014. Epub 2008 Mar 20.

uORFs, reinitiation and alternative translation start sites in human mRNAs.

Author information

1
Institute of Cytology and Genetics, Lavrentieva Avenue 10, Novosibirsk 630090, Russia. ak@bionet.nsc.ru

Abstract

It is known that eukaryotic ribosomes are able to translate small ORFs and reinitiate translation at downstream start codons. However, this mechanism is widely considered to be inefficient and it is not commonly taken into account. We compiled a sample of human mRNAs containing small upstream ORFs overlapping with annotated protein coding sequences. Statistical analysis supported the hypothesis on reinitiation of translation at downstream AUG codons and functional significance of potential alternative ORFs. It may be assumed that some 5'UTR-located upstream ORFs can deliver ribosomes to alternative translation starts, and they should be taken into consideration in the prediction of human mRNA coding potential.

PMID:
18358843
DOI:
10.1016/j.febslet.2008.03.014
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center