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Bioorg Med Chem Lett. 2008 Apr 1;18(7):2311-5. doi: 10.1016/j.bmcl.2008.02.080. Epub 2008 Mar 6.

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.

Author information

1
Abbott Laboratories, Cancer Research, 100 Abbott Park Road, Dept. R4N6 AP10-307, Abbott Park, IL 60064-6101, USA. lisa.hasvold@abbott.com

Abstract

The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.

PMID:
18358720
DOI:
10.1016/j.bmcl.2008.02.080
[Indexed for MEDLINE]

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