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Eur J Cancer. 1991;27(11):1393-5.

Verapamil upregulates sensitivity of human colon and breast cancer cells to LAK-cytotoxicity in vitro.

Author information

1
Cattedra di Oncologia Medica, II Facoltà di Medicina e Chirurgia, Università Federico II, Napoli, Italy.

Abstract

Pretreatment of human colon cancer LoVo-H cells and human breast cancer ZR-75 1A cells with low doses of verapamil, a Ca2+ channel blocker, for 48 h has a slight growth stimulatory effect and substantially increases cell sensitivity to lymphokine-activated killer (LAK) mediated cytotoxicity in the standard 51Cr release assay. The role of intracellular Ca2+ levels in determining verapamil effect is demonstrated by cytochemical evidence of intracellular Ca2+ lowering in verapamil-treated cells and by the reversal by the Ca2+ ionophore A-23187 of verapamil-induced sensitivity to LAK-mediated cytotoxicity.

PMID:
1835854
DOI:
10.1016/0277-5379(91)90018-9
[Indexed for MEDLINE]

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