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J Neurosci Methods. 2008 Jun 15;171(1):48-52. doi: 10.1016/j.jneumeth.2008.02.003. Epub 2008 Feb 12.

Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice.

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Université de Rouen, Faculté de Sciences, Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, Montréal, Québec, Canada H2X 3J4.


The relations between open-field, elevated plus-maze, and emergence tests were examined in two strains of mice. In the open-field, C57BL/6J mice had more ambulatory movements and rears but not stereotyped movements relative to BALB/c. In addition, C57BL/6J mice entered more often than BALB/c into enclosed and open arms of the elevated plus-maze. When placed inside a large enclosure, C57BL/6J mice emerged more quickly than BALB/c from a small toy object. In the entire series of mice, ambulation and rears in the open-field were linearly correlated with open and enclosed arm visits in the elevated plus-maze. Ambulatory movements and rears were also correlated with emergence latencies. In contrast, stereotyped movements were correlated with emergence latencies, but not with any elevated plus-maze value. These results specify the extent and limits of association between the three tests.

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