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Cell Death Differ. 2008 Jun;15(6):959-76. doi: 10.1038/cdd.2008.33. Epub 2008 Mar 21.

The dark side of a tumor suppressor: anti-apoptotic p53.

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  • 1Institute of Molecular Medicine, University of Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany. janicke@uni-duesseldorf.de

Abstract

Depending on multiple factors DNA damage leads either to cell cycle arrest or apoptosis. One of the main players deciding the fate of a cell is the tumor suppressor p53 that modulates these responses in a transcription-dependent and -independent manner. Over the past few years, however, strong evidence accumulated that p53 engages also powerful pro-survival pathways by transcriptionally activating a multitude of genes whose products efficiently counteract apoptosis. Our review summarizes the current knowledge concerning approximately forty p53-regulated proteins that exert their anti-apoptotic potential by interfering with diverse cellular processes. These activities are surely essential for normal development and maintenance of a healthy organism, but may easily turn into the dark side of the tumor suppressor p53 contributing to tumorigenesis.

PMID:
18356920
DOI:
10.1038/cdd.2008.33
[PubMed - indexed for MEDLINE]
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