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J Genet Genomics. 2008 Mar;35(3):183-8. doi: 10.1016/S1673-8527(08)60025-9.

The application of the entropy-based statistic for genomic association study of QTL.

Author information

1
College of Mathematics, Central South University, Changsha 410081, China.

Abstract

An entropy-based statistic T(PE) has been proposed for genomic association study for disease-susceptibility locus. The statistic T(PE) may be directly adopted and/or extended to quantitative-trait locus (QTL) mapping for quantitative traits. In this article, the statistic T(PE) was extended and applied to quantitative trait for association analysis of QTL by means of selective genotyping. The statistical properties (the type I error rate and the power) were examined under a range of parameters and population-sampling strategies (e.g., various genetic models, various heritabilities, and various sample-selection threshold values) by simulation studies. The results indicated that the statistic T(PE) is robust and powerful for genomic association study of QTL. A simulation study based on the haplotype frequencies of 10 single nucleotide polymorphisms (SNPs) of angiotensin-I converting enzyme genes was conducted to evaluate the performance of the statistic T(PE) for genetic association study.

PMID:
18355762
DOI:
10.1016/S1673-8527(08)60025-9
[Indexed for MEDLINE]

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