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BJOG. 2008 May;115(6):773-9. doi: 10.1111/j.1471-0528.2008.01690.x. Epub 2008 Mar 19.

Differential impact of conventional and low-dose oral hormone therapy, tibolone and raloxifene on mammographic breast density, assessed by an automated quantitative method.

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1
Department of Haematology and Faculty Division, UllevÄl University Hospital Trust, Oslo, Norway. a.l.eilertsen@medisin.uio.no

Abstract

OBJECTIVE:

To evaluate impact of different postmenopausal hormone therapy (HT) regimens and raloxifene on mammographic breast density.

DESIGN:

Open, randomised, comparative clinical trial.

SETTING:

Women were recruited through local newspapers and posters. They were examined at the Departments of Haematology, Gynaecology, and Radiology in a University Hospital.

POPULATION:

A total of 202 healthy postmenopausal women between the age of 45 and 65 years.

METHODS:

Women were randomly assigned to receive daily treatment for 12 weeks with tablets containing low-dose HT containing 1 mg 17 beta-estradiol + 0.5 mg norethisterone acetate (NETA) (n = 50), conventional-dose HT containing 2 mg 17 beta-estradiol and 1 mg NETA (n = 50), 2.5 mg tibolone (n = 51), or 60 mg raloxifene (n = 51). Mammographic density was determined at baseline and after 12 weeks by an automated technique in full-field digital mammograms.

MAIN OUTCOME MEASURES:

Mammographic density was expressed as volumetric breast density estimations.

RESULTS:

Mammographic breast density increased significantly and to a similar degree in both the conventional- and low-dose HT groups. A small reduction in mammographic breast density was seen in the raloxifene group, whereas those allocated to tibolone treatment only showed minor changes.

CONCLUSIONS:

Our findings demonstrated a significant difference in impact on mammographic breast density between the regimens. Although these results indicate a differential effect of these regimens on breast tissue, the relation to breast cancer risk remains unresolved.

[Indexed for MEDLINE]
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