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Mol Biosyst. 2008 Apr;4(4):300-8. doi: 10.1039/b718447f. Epub 2008 Feb 20.

Gene regulation technologies in zebrafish.

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  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Achieving the potential of zebrafish models in biomedical research is contingent on the development of reverse-genetic resources. This review describes current technologies for genetic perturbations in zebrafish, including an ecdysone receptor-based system that permits conditional transgene expression. Such methodologies promise to enable new zebrafish models for interrogating human physiology and disease.

PMID:
18354783
DOI:
10.1039/b718447f
[PubMed - indexed for MEDLINE]
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