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Nat Rev Mol Cell Biol. 2008 Apr;9(4):273-84. doi: 10.1038/nrm2378.

Exiting the Golgi complex.

Author information

1
Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (CH), Italy. dematteis@negrisud.it

Abstract

The composition and identity of cell organelles are dictated by the flux of lipids and proteins that they receive and lose through cytosolic exchange and membrane trafficking. The trans-Golgi network (TGN) is a major sorting centre for cell lipids and proteins at the crossroads of the endocytic and exocytic pathways; it has a complex dynamic structure composed of a network of tubular membranes that generate pleiomorphic carriers targeted to different destinations. Live-cell imaging combined with three-dimensional tomography has recently provided the temporal and topographical framework that allows the assembly of the numerous molecular machineries so far implicated in sorting and trafficking at the TGN.

PMID:
18354421
DOI:
10.1038/nrm2378
[Indexed for MEDLINE]

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