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J Virol. 2008 Jun;82(11):5657-63. doi: 10.1128/JVI.02556-07. Epub 2008 Mar 19.

New complex recombinant genotype of hepatitis B virus identified in Vietnam.

Author information

1
Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan.

Abstract

A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel intergenotypic recombination between genotypes A, C, and G. VH24 showed high similarity (98.3 to 98.9%) to the "aberrant strains" among Vietnamese isolates reported by Hannoun et al. (C. Hannoun et al., J. Gen. Virol. 81:2267-2272, 2000) and also had similar breakpoints of recombination. Phylogenetic analysis of the complete genome of these strains formed a separate clade. Furthermore, their pre-S/S gene-encoded seven unique conserved amino acid residues were not present in other genotypes. These findings support the designation of the new genotype I.

PMID:
18353958
PMCID:
PMC2395174
DOI:
10.1128/JVI.02556-07
[Indexed for MEDLINE]
Free PMC Article

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