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Trends Microbiol. 2008 Apr;16(4):173-80. doi: 10.1016/j.tim.2008.02.001. Epub 2008 Mar 18.

Staying alive: bacterial inhibition of apoptosis during infection.

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  • 1Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA.

Abstract

The ability of bacterial pathogens to inhibit apoptosis in eukaryotic cells during infection is an emerging theme in the study of bacterial pathogenesis. Prevention of apoptosis provides a survival advantage because it enables the bacteria to replicate inside host cells. Bacterial pathogens have evolved several ways to prevent apoptosis by protecting the mitochondria and preventing cytochrome c release, by activating cell survival pathways, or by preventing caspase activation. This review summarizes the most recent work on bacterial anti-apoptotic strategies and suggests new research that is necessary to advance the field.

PMID:
18353648
PMCID:
PMC2746948
DOI:
10.1016/j.tim.2008.02.001
[PubMed - indexed for MEDLINE]
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