Format

Send to

Choose Destination
See comment in PubMed Commons below
J Hosp Infect. 2008 Apr;68(4):308-14. doi: 10.1016/j.jhin.2008.01.033. Epub 2008 Mar 19.

Mortality of patients with antibiotic-associated diarrhoea: the impact of Clostridium difficile.

Author information

1
Infectious Diseases Unit, Rabin Medical Centre, Beilinson Hospital, Petah-Tiqwa and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. bishara@netvision.net.il

Abstract

Previous studies have shown conflicting results concerning mortality related to Clostridium difficile infection. The objective of this study was to determine the impact of C. difficile infection on short- and long-term mortality in hospitalised patients with antibiotic-associated diarrhoea. We therefore undertook a prospective case-control study of 217 hospitalised patients who received antibiotics, developed diarrhoea and underwent stool enzyme immunoassay for C. difficile TOX A/B. The Kaplan-Meier and the log-rank test were used to determine univariate survival analysis and a Cox regression model for multivariate analysis of 28 day and long-term mortality. Fifty-two (24%) of the 217 patients who met the study criteria were positive for C. difficile TOX A/B. The crude 28 day and long-term mortality rates of the entire cohort were 12.4% and 56%, respectively. On Cox regression analysis, hypoalbuminaemia, impaired functional capacity and elevated serum urea levels were found to be the only independent and statistically significant variables associated with long-term mortality. C. difficile toxin positivity per se was not associated with increased short- or long-term mortality rates. In conclusion, hypoalbuminaemia, renal failure, and impaired function capacity predict mortality due to antibiotic-associated diarrhoea, but C. difficile involvement by itself does not further increase the risk of death in these patients.

PMID:
18353491
DOI:
10.1016/j.jhin.2008.01.033
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center