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J Neurosurg Pediatr. 2008 Jan;1(1):95-8. doi: 10.3171/PED-08/01/095.

Desmoplastic infantile ganglioglioma with a malignant course.

Author information

1
Departments of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands. e.w.hoving@nchir.umcg.nl

Abstract

Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

PMID:
18352812
DOI:
10.3171/PED-08/01/095
[Indexed for MEDLINE]

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