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J Neurosurg Pediatr. 2008 Jan;1(1):95-8. doi: 10.3171/PED-08/01/095.

Desmoplastic infantile ganglioglioma with a malignant course.

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Departments of Neurosurgery, University Medical Center Groningen, Groningen, The Netherlands.


Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

[Indexed for MEDLINE]

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