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Wiad Lek. 2007;60(9-10):415-7.

[The assessment of the lipidogram and the proteinogram profile in patients with nonexudative age-related macular degeneration (AMD)].

[Article in Polish]

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1
Z Katedry i Zakładu Mikrobiologii i Immunologii Slaskiego Uniwersytetu Medycznego w Katowicach.

Abstract

The aim of the study was to assess the change in lipid and protein fraction patterns in patients with dry age-related macular degeneration (AMD) when compared against a control group.

MATERIAL AND METHOD:

Sample/research group: 37 nonexudative AMD patients; 14 men at the age of 52-80 and 23 women at the age of 50-80.

CONTROL GROUP:

15 people; 7 men at the age of 50-72 and 8 women at the age of 50-69. In both groups complete blood count, lipidogram, proteinogram, fibrinogen level and glycemia examinations were conducted. The statistical analysis of the received results was conducted with the use of the nonparametric chi square test assuming the level of significance p < or = 0.05.

RESULTS:

Research of plasma lipids concentration have shown the statistically significant correlation between the AMD occurrence and the tncreased level of the low-density lipoprotein (LDL) fraction and the total cholesterol at the significance level of p < or = 0.01, and at the same time, the lack of this correlation at p < or = 0.05 Research of the change in plasma protein level have shown the dependence solely between the AMD occurrence and the increased level of the alpha2-globulin fraction.

CONCLUSIONS:

Owning to the existing correlation between the increased level of the alpha2-globulin, LDL and the total cholesterol the AMD patient's or people remaining in the risk group should have their proteinogram and lipidogram examination conducted.

PMID:
18350713
[Indexed for MEDLINE]

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