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J Neural Transm (Vienna). 2008;115(4):637-40. doi: 10.1007/s00702-007-0864-8. Epub 2008 Mar 25.

Evidence based medicine in the use of botulinum toxin for back pain.

Author information

1
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA. bahman.jabbari@yale.edu

Abstract

Two randomized, prospective studies, one double blind and one open label, longterm evaluated efficacy and safety of Botulinum toxin A (Allergan-Inc) in 31 and 75 patients with chronic low back pain. Both studies used a novel technique imploying 5 level (L1 to L5) injections (40-50 units/level) of BoNT-A into erector spinae muscles. Significant (p < 0.05) improvement of pain intensity, frequency and activities of daily living was noted in 60% and 53% of the patients, respectively. The second study also depicted safety with repeated injections over 14 months of follow up. Botulinum toxin-A should be considered for treatment of low back pain when other modes of treatment fail to improve pain.

PMID:
18350247
DOI:
10.1007/s00702-007-0864-8
[Indexed for MEDLINE]

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