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Nature. 1991 Nov 7;354(6348):31-7.

Molecular cloning and characterization of the rat NMDA receptor.

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1
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.

Abstract

A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.

PMID:
1834949
DOI:
10.1038/354031a0
[Indexed for MEDLINE]
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