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J Surg Oncol. 2008 May 1;97(6):523-8. doi: 10.1002/jso.21025.

A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange.

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  • 1Department of Orthopaedic Surgery, Mie University Postgraduate School of Medicine, Tsu City, Japan. tomoki66@clin.medic.mie-u.ac.jp

Abstract

BACKGROUND:

To maintain excellent limb function after tumor resection in patients with high-grade malignant sarcomas, we developed and established a new surgical adjuvant therapy using acridine orange (AO) after intra-lesional or marginal resection while sparing normal tissues of major nerves, vessels or bones adjacent to the tumor.

METHOD:

Our AO therapy procedure was combined with photodynamic surgery (PDS), photodynamic therapy (PDT) and radiodynamic therapy (RDT). In this study, 26 patients with primary high-grade soft tissue sarcomas were treated with AO therapy.

RESULT:

Results showed a low local recurrence rate (7.7%) and good local recurrence-free rate (88%) after AO therapy. Limb function of all patients was maintained at 100% of ISOLS criteria.

CONCLUSION:

Based on these results, we concluded that AO therapy is useful for local control after margin-positive tumor resection and for preserving excellent limb function in patients with high-grade soft tissue sarcomas.

PMID:
18348188
DOI:
10.1002/jso.21025
[PubMed - indexed for MEDLINE]
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