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Cancer Lett. 2008 Jun 18;264(2):265-73. doi: 10.1016/j.canlet.2008.01.048. Epub 2008 Mar 17.

Regulation of the nitric oxide pathway genes by tetrahydrofurandiols: microarray analysis of MCF-7 human breast cancer cells.

Author information

1
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 405A, Houston, TX 77030, USA.

Abstract

THF-diols (9,12-oxy-10,13-dihydroxyoctadecanoic and 10,13-oxy-9,12-dihydroxyoctadecanoic acids) are endocrine disrupters in rats and mitogens in breast cancer cells. Microarray analyses and real-time PCR analyses on RNA from THF-treated MCF-7 cells revealed a number of genes (caveolin 1, heat shock protein 90 alpha and 90 beta, vascular endothelial growth factor, ATPase, Ca++ transporting, ubiquitous) in the nitric oxide pathway (NOP) were targets for THF-diols. Chromatin immunoprecipitation studies suggest THF-diols modify of histone H4 acetylation at the caveolin 1 promoter via an epigenetic mechanism. These findings are consistent with the well-known involvement of NOP genes in cell proliferation and sexual behavior.

PMID:
18346845
PMCID:
PMC2443634
DOI:
10.1016/j.canlet.2008.01.048
[Indexed for MEDLINE]
Free PMC Article

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