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J Vet Intern Med. 2008 Mar-Apr;22(2):357-65. doi: 10.1111/j.1939-1676.2008.0058.x. Epub 2008 Mar 10.

Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation.

Author information

1
Department of Small Animal Clinical Sciences, Faculty of Life Sciences, Small Animal Hospital, University of Copenhagen, Frederiksberg, Denmark. bwi@life.ku.dk

Abstract

BACKGROUND:

There is considerable variation in the coagulation profile of dogs with disseminated intravascular coagulation (DIC), making it difficult to assess overall hemostatic function.

OBJECTIVES:

To characterize the overall hemostatic state in dogs with DIC, by use of tissue factor-activated thromboelastography (TF-TEG), and to determine whether there is an association between hemostasis and outcome.

ANIMALS:

50 dogs with DIC.

METHODS:

Dogs admitted to the intensive care units, with an underlying disease known to predispose to DIC, were prospectively assessed with TF-TEG. Citrated blood samples were collected daily during hospitalization and an extended coagulation panel and TF-TEG were performed. Diagnosis of DIC was based on expert opinion.

RESULTS:

Hemostatic dysfunction was observed on the TF-TEG profile in 33/50 of the dogs, of which 22/50 were hypercoagulable and 11/50 were hypocoagulable based on the TF-TEG G value alone. There were significant differences in k, alpha, and MA values (P < .0001) among hypo-, normo-, and hypercoagulable dogs. There was a significant difference in case fatality rate between hypo- (64%) and hypercoagulable (32%) dogs (relative risk = 2.38; P= .04). Dogs that died had significantly lower antithrombin activity (P= .03) and higher d-dimer concentration (P= .03) than survivors.

CONCLUSIONS:

The most common overall hemostatic abnormality in dogs diagnosed with DIC was hypercoagulability, and there was significant difference in survival between hyper- and hypocoagulable dogs. The results suggest TF-TEG is valuable in the assessment of hemostatic function in dogs diagnosed with DIC.

PMID:
18346141
DOI:
10.1111/j.1939-1676.2008.0058.x
[Indexed for MEDLINE]
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