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Oncogene. 2008 Jul 10;27(30):4242-8. doi: 10.1038/onc.2008.56. Epub 2008 Mar 17.

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.

Author information

1
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, MA 2115, USA. dlangenau@enders.tch.harvard.edu

Abstract

The zebrafish has emerged as a powerful genetic model of cancer, but has been limited by the use of stable transgenic approaches to induce disease. Here, a co-injection strategy is described that capitalizes on both the numbers of embryos that can be microinjected and the ability of transgenes to segregate together and exert synergistic effects in forming tumors. Using this mosaic transgenic approach, gene pathways involved in tumor initiation and radiation sensitivity have been identified.

PMID:
18345029
PMCID:
PMC2680704
DOI:
10.1038/onc.2008.56
[Indexed for MEDLINE]
Free PMC Article

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