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Nat Methods. 2008 Apr;5(4):319-22. doi: 10.1038/nmeth.1195. Epub 2008 Mar 16.

A quantitative analysis software tool for mass spectrometry-based proteomics.

Author information

1
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SR11, La Jolla, California 92014, USA.

Abstract

We describe Census, a quantitative software tool compatible with many labeling strategies as well as with label-free analyses, single-stage mass spectrometry (MS1) and tandem mass spectrometry (MS/MS) scans, and high- and low-resolution mass spectrometry data. Census uses robust algorithms to address poor-quality measurements and improve quantitative efficiency, and it can support several input file formats. We tested Census with stable-isotope labeling analyses as well as label-free analyses.

PMID:
18345006
PMCID:
PMC3509211
DOI:
10.1038/nmeth.1195
[Indexed for MEDLINE]
Free PMC Article

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