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Acta Reumatol Port. 2008 Jan-Mar;33(1):17-33.

Tregs and rheumatoid arthritis.

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Musculoskeletal Research Group Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.


Regulatory T cells (Tregs) are a subset of T cells which are involved in peripheral immune tolerance. Their role in autoimmune disease which occurs through a breakdown of tolerance is of particular interest in trying to ascertain the mechanism(s) of disease progression. It is hoped that by understanding the role of Tregs in autoimmunity a reliable therapy may be developed to aid in both the treatment and potentially cure of disease. This review will focus on the naturally-occurring CD4+ CD25+ regulatory T cell subset and their possible involvement in rheumatoid arthritis.

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