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Appl Environ Microbiol. 2008 May;74(10):3291-4. doi: 10.1128/AEM.02719-07. Epub 2008 Mar 14.

High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112.

Author information

1
Kluyver Centre for Genomics of Industrial Fermentation, TI Food and Nutrition, and NIZO food research, Kernhemseweg 2, P.O. Box 20, 6710 BA Ede, The Netherlands.

Abstract

We observed that Lactobacillus reuteri JCM1112 produces B(12) and folate. However, the folate/B(12) mass ratio found was far below that desired for human consumption ( approximately 170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.

PMID:
18344331
PMCID:
PMC2394963
DOI:
10.1128/AEM.02719-07
[Indexed for MEDLINE]
Free PMC Article
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