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Eur J Cell Biol. 2008 Sep;87(8-9):507-15. doi: 10.1016/j.ejcb.2008.01.011. Epub 2008 Mar 17.

Adhesions ring: a structural comparison between podosomes and the immune synapse.

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  • 1Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.

PMID:
18343530
PMCID:
PMC2570187
DOI:
10.1016/j.ejcb.2008.01.011
[PubMed - indexed for MEDLINE]
Free PMC Article
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