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J Neuroimmunol. 2008 Mar;195(1-2):171-5. doi: 10.1016/j.jneuroim.2008.01.008. Epub 2008 Mar 17.

Neurological complications of celiac disease and autoimmune mechanisms: a prospective study.

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Department of Neurosciences, University of Padova, Padova, Italy.


Humoral immune mechanisms may have a role in the neurological complications of celiac disease (CD). We assessed 71 CD patients for neurologic manifestations and presence of serum antibodies to neural antigens. Sixteen patients (22.5%) were found to have neurological deficits including headache, depression, entrapment syndromes, peripheral neuropathy, and epilepsy. Antibody reactivity to neural antigens was detected in 30/71 (42.2%) patients. There was no clear correlation between anti-neural reactivity and neurologic dysfunction. Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet.

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