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Cancer Lett. 2008 Jun 8;264(1):101-6. doi: 10.1016/j.canlet.2008.01.043. Epub 2008 Mar 14.

Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression.

Author information

1
Department of neurosurgery, The First Affiliated Hospital of Suzhou University, Suzhou, China. johnhyl@netase.com

Abstract

Celastrol, a compound purified from Tripterygium wilfordii whose preparations have been used for clinical treatment for rheumatoid arthritis, has been demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. However, whether its antiangiogenic activity plays a role in the celastrol-mediated suppression of tumor growth and the molecular basis of anti-tumor activity are poorly understood. In this study, we found that celastrol inhibited the growth of human glioma xenografts in mice, which concurred with the suppression of angiogenesis. Interestingly, while celastrol had no effect on either the expression of VEGF or its mRNA levels, celastrol treatment lowered the expression levels of its receptors (VEGFR-1 and VEGFR-2) and their mRNA levels. These findings suggest that celastrol have potential to be used as an antiangiogenesis drug through its role in suppressing VEGF receptors expression that might consequently reduce the signal transduction between VEGF and VEGFR.

PMID:
18343027
DOI:
10.1016/j.canlet.2008.01.043
[Indexed for MEDLINE]

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