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Curr Opin Cell Biol. 2008 Apr;20(2):171-9. doi: 10.1016/j.ceb.2008.01.010. Epub 2008 Mar 14.

Epidermal Notch signalling: differentiation, cancer and adhesion.

Author information

1
Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. fiona.watt@cancer.org.uk

Abstract

The Notch pathway plays an important role in regulating epidermal differentiation. Notch ligands, receptors and effectors are expressed in a complex and dynamic pattern in embryonic and adult skin. Genetic ablation or activation of the pathway reveals that Notch signalling promotes differentiation of the hair follicle, sebaceous gland and interfollicular epidermal lineages and that Notch acts as an epidermal tumour suppressor. Notch signalling interacts with a range of other pathways to fulfil these functions and acts via RBP-Jkappa dependent and independent mechanisms. The effects on differentiation can be cell autonomous and non-autonomous, and Notch contributes to stem cell clustering via modulation of cell adhesion.

PMID:
18342499
PMCID:
PMC2324124
DOI:
10.1016/j.ceb.2008.01.010
[Indexed for MEDLINE]
Free PMC Article

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