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Genome Biol. 2008;9(3):213. doi: 10.1186/gb-2008-9-3-213. Epub 2008 Mar 4.

On the nature of thumbs.

Author information

1
Department of Ecology and Evolutionary Biology, Yale University, Prospect Street, New Haven, CT 06520-8106, USA. gunter.wagner@yale.edu

Abstract

Asymmetric regulation of Hox gene expression pre-dates the appearance of tetrapod digits, and was co-opted in the development of 'thumbness'. This asymmetric expression correlates with independent morphological evolutionary variation of digit 1.

PMID:
18341703
PMCID:
PMC2397496
DOI:
10.1186/gb-2008-9-3-213
[Indexed for MEDLINE]
Free PMC Article
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