Format

Send to

Choose Destination
Int J Paediatr Dent. 2008 May;18(3):170-7. doi: 10.1111/j.1365-263X.2007.00912.x. Epub 2008 Mar 12.

Effect of xylitol and xylitol-fluoride lozenges on approximal caries development in high-caries-risk children.

Author information

1
Department of Odontology, Paediatric Dentistry, Faculty of Medicine, Umeå University, Umeå, Sweden. christina.stecksenblicks@odont.umu.se

Abstract

AIM:

To evaluate the effect of xylitol- and xylitol/fluoride-containing lozenges on approximal caries development in young adolescents with high caries risk.

STUDY DESIGN:

A 2-year double-blind trial with two parallel arms and a nonrandomized reference group.

MATERIAL AND METHODS:

One hundred and sixty healthy 10- to 12-year-old children with high caries risk were selected. After informed consent, they were randomly assigned into a xylitol and a xylitol/fluoride group. They were instructed to take two tablets three times a day (total xylitol and fluoride dose 2.5 g and 1.5 mg, respectively). The compliance was checked continuously and scored as good, fair, or poor. A reference no-tablet group was also selected (n = 70) for group comparison. The outcome measure was approximal caries incidence.

RESULTS:

The dropout rate was 28%, and 41% exhibited a good compliance with the study protocol. No statistically significant differences in caries incidence could be found between the study groups (P > 0.05). Among a subgroup of children who demonstrated good compliance, the mean DeltaDMFSa value was significantly lower in the xylitol/fluoride group compared to the xylitol group, 1.0 +/- 2.3 vs. 3.3 +/- 4.6 (P < 0.05), while no difference could be displayed between any of the study groups and the reference group (P > 0.05).

CONCLUSION:

The results from this 2-year trial did not support a self-administered regimen of xylitol- or xylitol/fluoride-containing lozenges for the prevention of approximal caries in young adolescents with high caries risk.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center