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Rejuvenation Res. 2008 Apr;11(2):287-91. doi: 10.1089/rej.2008.0665.

Modulation of genes involved in zinc homeostasis in old low-grade atherosclerotic patients under effects of HMG-CoA reductase inhibitors.

Author information

1
Immunology Center, Section of Nutrition, Immunity and Ageing, Research Department, INRCA, Ancona, Italy. lauracostarelli@hotmail.com

Abstract

Taking into account the antioxidant properties of zinc, it is difficult to explain the beneficial effects of HMG-CoA reductase inhibitors in the context of a well-known decreased zinc status. Therefore, intracellular zinc homeostasis was studied in patients with low-grade carotid atherosclerosis under treatment with HMG-CoA reductase inhibitors using a custom microarray-based approach developed by pooling information across microarray studies. Experimental data unravel an active zinc signaling in PBMC from low-grade atherosclerotic patients under lipid reduction therapy, suggesting that monitoring intracellular zinc status could be a key factor for an optimal strategy and targeting a level of intervention.

PMID:
18341426
DOI:
10.1089/rej.2008.0665
[Indexed for MEDLINE]

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