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Kidney Int. 2008 Apr;73(7):797-9. doi: 10.1038/ki.2008.15.

Low oxygen stimulates the immune system.

Author information

1
Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. maltz@mail.med.upenn.edu

Abstract

Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.

PMID:
18340350
PMCID:
PMC3791324
DOI:
10.1038/ki.2008.15
[Indexed for MEDLINE]
Free PMC Article

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