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J Invest Dermatol. 2008 Apr;128(4):773-5. doi: 10.1038/jid.2008.35.

Vitamin D regulation of cathelicidin in the skin: toward a renaissance of vitamin D in dermatology?

Author information

1
Department of Dermatology, University Hospital Leuven, Belgium. Siegfried.Segaert@med.kuleuven.be

Abstract

1,25-Dihydroxyvitamin D(3), the active form of vitamin D, is a major regulator of the expression of the cationic antimicrobial peptide cathelicidin, not only in monocytes but also in epidermal keratinocytes. The involvement of cathelicidin in wound healing and skin diseases as diverse as psoriasis, rosacea, and atopic dermatitis may create new opportunities for the use of vitamin D in dermatology.

PMID:
18337709
DOI:
10.1038/jid.2008.35
[Indexed for MEDLINE]
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