Abstract
Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its over-expression leads to preeclampsia-like symptoms.
MeSH terms
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Animals
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Female
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Humans
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Hypoxia / blood
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Hypoxia / physiopathology
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Placenta Growth Factor
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Pre-Eclampsia / physiopathology*
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Pregnancy
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Pregnancy Proteins / blood
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Pregnancy Proteins / metabolism*
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Solubility
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Vascular Endothelial Growth Factor A / blood
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Vascular Endothelial Growth Factor A / metabolism
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Vascular Endothelial Growth Factor Receptor-1 / blood
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Vascular Endothelial Growth Factor Receptor-1 / metabolism*
Substances
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PGF protein, human
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Pregnancy Proteins
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Vascular Endothelial Growth Factor A
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Placenta Growth Factor
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FLT1 protein, human
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Vascular Endothelial Growth Factor Receptor-1