A possible placental factor for preeclampsia: sFlt-1

Curr Med Chem. 2008;15(7):711-5. doi: 10.2174/092986708783885309.

Abstract

Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its over-expression leads to preeclampsia-like symptoms.

Publication types

  • Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Hypoxia / blood
  • Hypoxia / physiopathology
  • Placenta Growth Factor
  • Pre-Eclampsia / physiopathology*
  • Pregnancy
  • Pregnancy Proteins / blood
  • Pregnancy Proteins / metabolism*
  • Solubility
  • Vascular Endothelial Growth Factor A / blood
  • Vascular Endothelial Growth Factor A / metabolism
  • Vascular Endothelial Growth Factor Receptor-1 / blood
  • Vascular Endothelial Growth Factor Receptor-1 / metabolism*

Substances

  • PGF protein, human
  • Pregnancy Proteins
  • Vascular Endothelial Growth Factor A
  • Placenta Growth Factor
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1