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Clin Lab Sci. 2008 Winter;21(1):15-8.

Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review.

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  • 1University of Southern Mississippi, Hattiesburg, MS, USA.


For many years, laboratory diagnosis of rheumatoid arthritis has relied on the detection of rheumatoid factor. A new assay that detects antibodies to citrullinated peptides, called the anti-CCP assay, has demonstrated a comparable sensitivity but a much higher specificity than the RF test. This paper reviews RF and anti-CCP in rheumatoid arthritis and examines the usefulness of each autoantibody in RA testing.

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