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J Affect Disord. 2008 Nov;111(1):61-6. doi: 10.1016/j.jad.2008.02.005. Epub 2008 Mar 11.

Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fracture.

Author information

1
Department of Psychiatry, Washington University School of Medicine, United States. lenzee@psychiatry.wustl.edu

Abstract

BACKGROUND:

Depression is common after hip fracture and is associated with poorer functional recovery. Polymorphisms of the serotonin 1a (5HTR1A) and 2a receptors (5HTR2A) are associated with depression; therefore, we examined their association with depressive symptoms and functional recovery after hip fracture.

METHODS:

145 elderly women were followed for 12 months after hip fracture. Depressive symptoms were measured with the 15-item Geriatric Depression Scale (GDS). Functional status was measured by Lower Extremity Physical and Instrumental Activity of Daily Living scales (LPADLs and IADLs). Time-adjusted general linear regression models compared mean GDS between those with and without risk alleles for 5HTR1A and 5HTR2A.

RESULTS:

Women with 1-2 copies of the 5HTR1A (-1019) G allele had higher GDS scores (Adjusted Mean Difference=0.59; 95% CI, 0.12-1.06), and poorer IADL scores (Adjusted Mean Difference=0.24; 95%CI -0.002 to 0.49), compared to those without this allele, controlling for potential confounders and 5HTR2A. Depressive symptoms partly accounted for poorer IADL recovery. Women with 1-2 copies of the 5HTR2A (-1438) C allele did not have significantly higher GDS scores (Adjusted Mean Difference=0.34; 95%CI, -0.20 to 0.87) and had better IADL scores (Adjusted Mean Difference=-0.40; 95%CI -0.74 to 0.06) than those with A/A genotype.

LIMITATIONS:

The findings are limited by small sample size and the use of a screening scale to measure depression.

CONCLUSIONS:

The 5HTR1A (-1019) G allele is associated with increased depressive symptoms after hip fracture, which in turn accounts for poorer functional recovery. These results suggest a role for serotonergic genetic variation in elderly persons' resilience and recovery from medical events.

PMID:
18334271
PMCID:
PMC2610462
DOI:
10.1016/j.jad.2008.02.005
[Indexed for MEDLINE]
Free PMC Article

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