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Adv Chronic Kidney Dis. 2008 Apr;15(2):101-6. doi: 10.1053/j.ackd.2008.01.001.

Intrauterine growth restriction: fetal programming of hypertension and kidney disease.

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1
Department of Physiology, University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.

Abstract

The etiology of hypertension historically includes 2 components: genetics and lifestyle. However, recent epidemiologic studies report an inverse relationship between birth weight and hypertension suggesting that a suboptimal fetal environment may also contribute to increased disease in later life. Experimental studies support this observation and indicate that cardiovascular/kidney disease originates in response to fetal adaptations to adverse conditions during prenatal life.

PMID:
18334233
PMCID:
PMC2322936
DOI:
10.1053/j.ackd.2008.01.001
[Indexed for MEDLINE]
Free PMC Article
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