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Respiration. 2008;75(2):121-33. doi: 10.1159/000113629. Epub 2008 Mar 6.

Pathophysiology of the pleura.

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1
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Fla, USA.

Abstract

The pleural mesothelial cell is an essential cell in maintaining the normal homeostasis of the pleural space and it is also a central component of the pathophysiologic processes affecting the pleural space. In this review, we will review the defense mechanisms of the pleural mesothelium and changes in pleural physiology as a result of inflammatory, infectious, and malignant conditions with a focus on cytokine and chemokine networks. We will also review the processes involved in the pathogenesis of pleural fibrosis.

PMID:
18332619
DOI:
10.1159/000113629
[Indexed for MEDLINE]
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