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Yi Chuan. 2008 Mar;30(3):295-303.

[Microarray-based methods to identify DNA methylation in cancer].

[Article in Chinese]

Author information

  • 1Shanghai Jiaotong University School of Medicine, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai 200001, China.


DNA methylation is an epigenetic modification associated with gene transcription regulation, X-chromosome inactivation, regulation of development and cell differentiation. Aberrant DNA methylation has been linked to cancer. The advent of microarray technology has provided new opportunities for high-throughput study on DNA methylation. Various microarray-based methods depend on different pretreatments including immunoprecipitation and restriction digestion. Al-though each technique has its limitations, the immunoprecipitation method has high specificity, and the restriction digestion method shows high sensitivity. Together they provide many choices to the study of genome-wide DNA methylation profile in cancer.

[PubMed - indexed for MEDLINE]
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