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Bioorg Med Chem Lett. 2008 Apr 1;18(7):2509-12. doi: 10.1016/j.bmcl.2007.07.068. Epub 2007 Aug 21.

Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors.

Author information

1
Millennium Pharmaceuticals, 35 Landsdowne Street, Cambridge, MA 02139, USA. gharriman@galenea.com

Abstract

A novel series of barbituric acid derivatives were identified as selective inhibitors of alpha4beta7 MAdCAM (mucosal addressin cell adhesion molecule-1) interactions via a high throughput screening exercise. These inhibitors were optimized to submicromolar potencies in whole cell adhesion assays, retaining their selectivity over alpha4beta1 VCAM.

PMID:
18331794
DOI:
10.1016/j.bmcl.2007.07.068
[Indexed for MEDLINE]

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