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Mol Microbiol. 2008 May;68(3):538-46. doi: 10.1111/j.1365-2958.2008.06181.x. Epub 2008 Mar 4.

Modus operandi of the bacterial RNA polymerase containing the sigma54 promoter-specificity factor.

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Department of Microbiology, Division of Investigative Sciences, Faculty of Medicine and Centre for Molecular Microbiology and Infection, Imperial College London, SW7 2AZ, UK.


Bacterial sigma (sigma) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative sigma factor sigma(54) confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the sigma(54) factor makes with the bacterial transcription machinery.

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