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J Psychiatry Neurosci. 2008 Mar;33(2):142-6.

Rostral anterior cingulate volume predicts treatment response to cognitive-behavioural therapy for posttraumatic stress disorder.

Author information

1
Brain Dynamics Centre, Westmead Hospital, Sydney, Australia. r.bryant@unsw.edu.au

Abstract

OBJECTIVE:

To index the extent to which treatment response in posttraumatic stress disorder (PTSD) is predicted by rostral anterior cingulate cortex (rACC) volume.

METHOD:

We used structural magnetic resonance imaging in a 1.5 T scanner to examine subjects with PTSD (n = 13), traumatized control subjects (n = 13) and nontraumatized control subjects (n = 13). Subjects with PTSD then participated in 8 sessions of cognitive-behavioural therapy, after which we reassessed them for PTSD.

RESULTS:

According to voxel-based morphometry, treatment responders had larger rACC volume than nonresponders. Further, symptom reduction was associated with larger rACC volume.

CONCLUSION:

Consistent with evidence for the neural bases of extinction learning, PTSD patients with larger rACC volume may be better able to regulate fear during cognitive-behavioural therapy and thus achieve greater treatment gains.

KEYWORDS:

cognitive therapy; magnetic resonance imaging; stress disorders, post-traumatic

PMID:
18330460
PMCID:
PMC2265310
[Indexed for MEDLINE]
Free PMC Article

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