Format

Send to

Choose Destination
Vaccine. 2008 Mar 28;26(15):1863-1873. doi: 10.1016/j.vaccine.2008.01.052. Epub 2008 Feb 20.

Age-dependent tolerance to an endogenous tumor-associated antigen.

Author information

1
Integrated Department of Immunology, University of Colorado, Denver.
2
Department of Microbiology, University of Virginia School of Medicine.
#
Contributed equally

Abstract

Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26. We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immunologic tolerance and affects antitumor immunity in a similarly age-dependent manner using gp70-deficient mice. We found that tumors grew in all gp70-sufficient mice, while approximately half of gp70-deficient mice controlled tumor growth with endogenous T-cell responses. Protection in gp70-deficient mice correlated with more robust gp70-specific CTL responses, and increased numbers and avidity of responding antigen-specific T cells after vaccination. We conclude that immunosurveillance may decline with age due to increased or de novo peripheral expression of endogenous TAAs.

PMID:
18329760
PMCID:
PMC2295286
DOI:
10.1016/j.vaccine.2008.01.052
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center