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Rheum Dis Clin North Am. 2008 Feb;34(1):57-71; vi. doi: 10.1016/j.rdc.2007.12.004.

Vascular disease in scleroderma: mechanisms of vascular injury.

Author information

1
Division of Rheumatology and Immunology, University of Toledo Medical Center, 3120 Glendale Avenue, Toledo, OH 43617, USA. bashar.kahaleh@utoledo.edu

Abstract

Vascular endothelial injury in systemic sclerosis (SSc) includes a spectrum of changes that involve predominantly the microcirculation and arterioles. The pathologic changes in the blood vessels adversely impact the physiology of many organ systems, with a reduction in the size of microvascular beds leading to decreased organ blood flow and ultimately to a state of chronic ischemia. Current hypotheses in SSc vascular disease suggest a possible chemical or infectious trigger.

PMID:
18329532
DOI:
10.1016/j.rdc.2007.12.004
[Indexed for MEDLINE]

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