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Trends Endocrinol Metab. 2008 May-Jun;19(4):146-52. doi: 10.1016/j.tem.2007.12.001. Epub 2008 Mar 7.

Metabolic programming in the immediate postnatal period.

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Department of Biochemistry, University at Buffalo, The State University of New York, 140 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA.


In recent decades, there has been a dramatic increase in the incidence of obesity in all age groups of the population in the USA. In addition to genetics and life style changes, the important role of metabolic programming effects in the etiology of the obesity epidemic is being increasingly recognized. Although the role of a compromised intrauterine environment in fetal metabolic programming is well documented to contribute to the development of adult-onset diseases, vulnerability in the immediate postnatal period to similar conditions has also been shown. Metabolic programming effects induced by altered nutritional experiences in the immediate postnatal period can give rise to long-term consequences in the context of the current obesity epidemic.

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