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FEBS Lett. 2008 Jun 18;582(14):2004-16. doi: 10.1016/j.febslet.2008.02.067. Epub 2008 Mar 6.

Nuclear pore complex assembly through the cell cycle: regulation and membrane organization.

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Friedrich Miescher Laboratory of the Max-Planck-Society, Spemannstrasse 39, 72076 Tübingen, Germany.


In eukaryotes, all macromolecules traffic between the nucleus and the cytoplasm through nuclear pore complexes (NPCs), which are among the largest supramolecular assemblies in cells. Although their composition in yeast and metazoa is well characterized, understanding how NPCs are assembled and form the pore through the double membrane of the nuclear envelope and how both processes are controlled still remains a challenge. Here, we summarize what is known about the biogenesis of NPCs throughout the cell cycle with special focus on the membrane reorganization and the regulation that go along with NPC assembly.

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