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Fertil Steril. 2009 Apr;91(4):998-1004. doi: 10.1016/j.fertnstert.2008.01.029. Epub 2008 Mar 6.

Pathophysiologic features of "thin" endometrium.

Author information

1
Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Abstract

OBJECTIVE:

To characterize pathophysiologic features of a "thin" endometrium.

DESIGN:

A prospective observational study.

SETTING:

University Hospital and City General Hospital.

PATIENT(S):

Patients with normal-thickness endometrium (Normal-Em group: endometrial thickness >or=8 mm; n = 57) and thin endometrium (Thin-Em group: endometrial thickness <8 mm; n = 17).

MAIN OUTCOME MEASURE(S):

Blood flow impedance of the uterine radial artery (RA) was assessed as resistance index (RI) by transvaginal color-pulsed Doppler ultrasonography. The area of glandular epithelium, the number of blood vessels, and vascular endothelial growth factor (VEGF) expression were examined in the midluteal-phase endometrium.

RESULT(S):

The RA-RI in the Thin-Em group was significantly higher than in the Normal-Em group throughout the menstrual cycle. Endometrial thickness was significantly correlated with RA-RI. Growth of glandular epithelium, the number of blood vessels, and VEGF expression were significantly lower in the Thin-Em group than in the Normal-Em group.

CONCLUSION(S):

A "thin" endometrium was characterized by high blood flow impedance of RA, poor epithelial growth, decreased VEGF expression, and poor vascular development.

[Indexed for MEDLINE]

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