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Pediatr Blood Cancer. 2008 Jul;51(1):99-104. doi: 10.1002/pbc.21544.

A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia.

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  • 1Division of Child Behavioral Health, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Michigan, USA. catpeter@med.umich.edu

Abstract

BACKGROUND:

Mixed findings on the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia (ALL), without radiation, indicate the need for a comprehensive meta-analytic review. The purpose of the current study was to conduct a meta-analysis assessing neuropsychological and academic functioning differences between children with ALL treated solely with chemotherapy and comparison groups.

PROCEDURE:

Thirteen articles met inclusion criteria for the meta-analysis and were analyzed using a random effects model, weighted least squares methods.

RESULTS:

Mean effect sizes were significantly different from zero for multiple domains of intelligence and academic achievement; processing speed; verbal memory; and some aspects of executive functioning and fine motor skills, indicating worse functioning in ALL survivors. Effect sizes for visual-motor skills and visual memory were not significantly different from zero.

CONCLUSIONS:

Results support the presence of neuropsychological and academic sequelae for ALL survivors treated solely with chemotherapy and highlight the need for ongoing follow-up of children with ALL using a standardized neuropsychological test battery and research methodology.

PMID:
18322925
DOI:
10.1002/pbc.21544
[PubMed - indexed for MEDLINE]
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