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Arch Gynecol Obstet. 2008 Nov;278(5):437-41. doi: 10.1007/s00404-008-0611-x. Epub 2008 Mar 6.

The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study.

Author information

1
Departments of Obstetrics and Gynecology, Izmir Training and Research Hospital, Izmir, Turkey. drigulhan@yahoo.com

Abstract

OBJECTIVE:

The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women.

STUDY DESIGN:

Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment.

RESULTS:

Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin.

CONCLUSION:

Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.

PMID:
18322691
DOI:
10.1007/s00404-008-0611-x
[Indexed for MEDLINE]

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