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J Virol. 2008 May;82(10):5099-103. doi: 10.1128/JVI.01993-07. Epub 2008 Mar 5.

Genomic analysis of closely related astroviruses.

Author information

1
Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA.

Abstract

To understand astrovirus biology, it is essential to understand factors associated with its evolution. The current study reports the genomic sequences of nine novel turkey astrovirus (TAstV) type 2-like clinical isolates. This represents, to our knowledge, the largest genomic-length data set available for any one astrovirus type. The comparison of these TAstV sequences suggests that the TAstV species contains multiple subtypes and that recombination events have occurred across the astrovirus genome. In addition, the analysis of the capsid gene demonstrated evidence for both site-specific positive selection and purifying selection.

PMID:
18321976
PMCID:
PMC2346738
DOI:
10.1128/JVI.01993-07
[Indexed for MEDLINE]
Free PMC Article

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