Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Hum Genet. 2008 Mar;82(3):748-55. doi: 10.1016/j.ajhg.2007.12.014.

Estimating ethnic admixture from pedigree data.

Author information

1
Department of Human Genetics, The University of California, Los Angeles, CA 90095, USA. janet@mednet.ucla.edu

Abstract

This paper introduces a likelihood method of estimating ethnic admixture that uses individuals, pedigrees, or a combination of individuals and pedigrees. For each founder of a pedigree, admixture proportions are calculated by conditioning on the pedigree-wide genotypes at all ancestry-informative markers. These estimates are then propagated down the pedigree to the nonfounders by a simple averaging process. The large-sample standard errors of the founders' proportions can be similarly transformed into standard errors for the admixture proportions of the descendants. These standard errors are smaller than the corresponding standard errors when each individual is treated independently. Both hard and soft information on a founder's ancestry can be accommodated in this scheme, which has been implemented in the genetic software package Mendel. The utility of the method is demonstrated on simulated data and a real data example involving Mexican families of mixed Amerindian and Spanish ancestry.

PMID:
18319077
PMCID:
PMC2427215
DOI:
10.1016/j.ajhg.2007.12.014
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center